Novel Cell-Free Peptide Therapeutics for Cardiac Repair and Regeneration

Grant Project Details:

John C. Burnett, Jr, MD
Mayo Clinic | Rochester, MN
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Grant timeline: proposal, updates, reports

Grant Location

Mayo Clinic
200 1st St SW
Rochester, MN 55905

Grant Description


Our goal is to establish that the use of a novel Mayo Clinic engineered peptide will serve as an innovative cell-free peptide therapeutic strategy for cardiac repair and regeneration in experimental permanent myocardial injury. Success will be defined as establishing in vitro and/or in vivo suppression of apoptosis, induction of angiogenesis and inhibition of fibrosis in the injured heart.  Success will lead to rapid acceleration to IND readiness so as to translate findings into future clinical trials and potentially patient use and commercialization.

Grant Awardee Biography

image of John C. Burnett, Jr, MD

Dr. Burnett is a Professor of Medicine and of Physiology at Mayo Clinic. He has been the Marriott Family Cardiovascular Research Professor there since 2007.