Discovery Knows No Bounds

Discovery knows no bounds

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Current Awards

These are currently funded research projects

Transcatheter regenerative tissue pulmonary valve

Research Grant Recipient: Zeeshan Syedain, PhD

Award Value: $250,000

Research Focus: Cardiovascular disease

From the investigator:

The goal of this translational research project is to generate preclinical data and demonstrate regenerative engineered tissue as a superior tissue replacement over fixed pericardium for a pulmonary valve replacement in young patients.

Zeeshan Syedain, PhD

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Regenerative strategy for volumetric muscle loss and functional recovery

Research Grant Recipient: Steven Moran, MD

Award Value: $250,000

Research Focus: regeneration of muscle

From the investigator:

The main goal of the project is to develop a therapeutic strategy for the regeneration of muscle volume and recovery of function after traumatic volumetric muscle loss.

Steven Moran, MD

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Activating the Hippo pathway effector YAP to augment liver regeneration

Research Grant Recipient: Rory Smoot, MD

Award Value: $250,000

Research Focus: regenerating the liver

From the investigator:

The goal of this proposal is to speed up liver regeneration by activation a regeneration pathway with a drug treatment. This will be tested in multiple models, including models in which regeneration is not as good at baseline. Positive results would provide a potential treatment to improve liver function in patients suffering from liver failure.

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Treating osteogenesis imperfecta by inhibiting the PRC2 complex

Research Grant Recipient: David Deyle, MD

Award Value: $250,000

Research Focus: Skeletal regeneration, brittle bone disease

From the investigator:

The goal of this proposal is to develop a new strategy for skeletal regeneration in patients who have osteogenesis imperfecta (OI) or brittle bone disease using epigenetics regulators that alter gene expression. We have shown that inhibiting a epigenetic regulator, PCR2, increases bone formation in normal mice and will determine if this also occurs in OI mice. We will also investigate if a small molecule that inhibits the PRC2 complex can also increase bone formation in OI mice and cells from OI patients.

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Safety Evaluation of Intracoronary infusion of extracellular vesicles in patients with AMI (EV‐AMI)

Research Grant Recipient: Atta Behfar, MD, PhD

Award Value: $492,778

Research Focus: Heart attack (acute myeocardial infarction)

From the investigator:

This research tests a new product for patients who have had a heart attack (AMI, acute myeocardial infarction). This product would help protect and regenerate cells in a heart damaged by AMI.

Rion is a clinical‐phase regenerative medicine company based in Rochester, MN, focused on bringing novel regenerative technologies solving unmet medical needs of the people of Minnesota.

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