Discovery Knows No Bounds

Discovery knows no bounds

Copyright 2016 RMM.

Current Awards

These are currently funded research projects

Neuroprotection Using Human Extremely Low Gestational Age Neonate-Derived Umbilical Cord Blood Stem Cells in Neonatal Hemorrhagic Brain Injury

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Regenerative vein valve

Research Grant Recipient: Robert Tranquillo, PhD

Award Value: $250,000

Research Focus: Chronic venous insufficiency

Project Summary: Millions of U.S. citizens suffer from vein valve insufficiency, often resulting in chronic leg ulcers that cause pain, immobility, and a reduced quality of life. The goal of this research is to develop tissue-engineered vein valve, an “off-the-shelf” implantable device. If successful, it will be the first prosthetic vein valve available to treat suffering from ulcers due to chronic venous insufficiency.

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Engineering microcapsules for stem cell cultivation and transplantation

Research Grant Recipient: Alexander Revzin, PhD

Award Value: $249,998

Research Focus: Diabetes

Project Summary: The goal of this project is to develop microcapsules that could be used as cell carriers during differentiation of stem cells into pancreatic islets. These same capsules may also be useful as vehicles for islet transplantation. Developing this technology will enable better scale-up of islet production from stem cells, may result in cost reduction, and may also alleviate problems associated with immune rejection of transplanted islets.

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Regeneration of hypothalamic neuro-architecture using liver enzyme gene transfer as an approach to treat post-dieting body weight rebound

Research Grant Recipient: Ping Chen, PhD

Award Value: $250,000

Research Focus: Obesity

Project Summary: The major challenge in treating obesity is not just losing weight, but preventing weight from coming back. This proposal examines a new treatment strategy of using a gene transfer therapy to safely target brain mechanisms that control hunger and energy output. The investigator’s previous research indicates that gene transfer of a well-tolerated liver enzyme could revolutionize clinical treatment of obesity, making it easier for obese patients to lose weight safely and minimize later weight gain.

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CELLTOP: A Phase I Clinical Trial of Autologous Adipose Derived Mesenchymal Stem Cells in the Treatment of Paralysis due to Traumatic Spinal Cord Injury

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The RECLAIM trial for focal cartilage repair

Research Grant Recipient: Aaron Krych, MD

Award Value: $498,000

Research Focus: Cartilage regeneration

Project Summary: The goals of this project are to test the initial safety and feasibility of RECLAIM, a single stage cartilage repair technique using the patient’s own cartilage cells and allogeneic mesenchymal stem cells.  The study will assess patient’s improvement in pain and function following the procedure, while actively monitoring safety and adverse events.

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Girk channels in cartilage development and repair

Research Grant Recipient: Jennifer Westendorf, PhD

Award Value: $250,000

Research Focus: Osteoarthritis

Project Summary: This project will help determine how proteins called Girk2 and Girk3 contribute to cartilage formation and repair in the setting of osteoarthritis. The investigators believe that osteoarthritis can be prevented if these proteins are absent or inactive. This work will lead to the development of better strategies to treat osteoarthritis.

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