Mayo CRM-original iPSC-derived islet product in a retrievable, encapsulation device

Our product is MC-iLETS01, Mayo Center for Regenerative Medicine-original iPSC-derived islet cell product in a retrievable encapsulation device, for diabetes therapy. We will test its long-term safety/functionality in a mouse model of diabetes. The data will be used for our FDA pre-IND and IND applications.

Mayo Clinic
Yasuhiro Ikeda, DVM, PhD
2017-2018

Development of inducible immunodeficient swine

Immunodeficient swine have tremendous potential in basic and pre-clinical research; however, difficulties in propagation have impeded commercial availability.  As a solution, we propose to build and test a conditional rescue cassette to pair with our RAG2/IL2Rg knockout swine to enable propagation.  If successful, this project will lead to the first commercially available immunodeficient pig for regenerative medicine research and development.

Recombinetics
Daniel Carlson, PhD
2017-2018

Fetoscopic regenerative therapy for severe pulmonary hypoplasia - a feasibility pre-randomized controlled trial study

When a baby’s lungs are not adequately developed at birth, severe complications and even death can result. Dr. Ruano brings expertise in a technique that uses a minimally invasive procedure to intervene while the fetus is still in the uterus. He will participate as one investigator in a larger clinical trial to see if this procedure can regenerate the process of lung growth and development before birth.

Year One Progress Report:

Mayo Clinic
Rodrigo Ruano, MD, PhD

Spinal cord regeneration: translating from salamanders to enhance regenerative repair after injury in mammals

Some salamanders can regenerate a fully functional spinal cord after injury, but humans and other mammals can’t. Dr. Echeverri’s research has identified key molecular differences between salamanders and mammals. She is working to learn more about these differences and how processes in the salamander could be translated to help mammals regenerate spinal tissue.

Year One Progress Report:

University of Minnesota
Karen Echeverri, PhD

Generation of second heart field and head muscle progenitors by modeling cardiopharyngeal mesoderm

Some common birth defects affect the muscles of both a child’s face and heart. Dr. Chan is working on a pluripotent stem cell model that produces these muscles to better understand what types of cells could some day help treat these patients.

Year One Progress Report:

University of Minnesota
Sunny Chan, PhD