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Treating osteogenesis imperfecta by inhibiting the PRC2 complex

Research Grant Recipient: David Deyle, MD

Award Value: $250,000

Research Focus: Skeletal regeneration, brittle bone disease

From the investigator:

The goal of this proposal is to develop a new strategy for skeletal regeneration in patients who have osteogenesis imperfecta (OI) or brittle bone disease using epigenetics regulators that alter gene expression. We have shown that inhibiting a epigenetic regulator, PCR2, increases bone formation in normal mice and will determine if this also occurs in OI mice. We will also investigate if a small molecule that inhibits the PRC2 complex can also increase bone formation in OI mice and cells from OI patients.

David Deyle, MD