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Safety and mechanisms of senolytic therapy for central nervous system rejuvenation

Research Grant Recipient: Terence Burns, MD, PhD

Award Value: $249,118

Research Focus: Cognitive impairment

Project Summary: The decline of memory and thinking processes seen in aging, neurodegenerative diseases (like Alzheimer’s disease), and exposure of the brain to radiation, are believed to be caused in part by senescence (gradual deterioration) of stem cells in the brain. This study examines if selectively allowing these deteriorated cells to die will combat damage to the central nervous system, and if it is safe and effective.

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