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Regeneration of hypothalamic neuro-architecture using liver enzyme gene transfer as an approach to treat post-dieting body weight rebound

Research Grant Recipient: Ping Chen, PhD

Award Value: $250,000

Research Focus: Obesity

Project Summary: The major challenge in treating obesity is not just losing weight, but preventing weight from coming back. This proposal examines a new treatment strategy of using a gene transfer therapy to safely target brain mechanisms that control hunger and energy output. The investigator’s previous research indicates that gene transfer of a well-tolerated liver enzyme could revolutionize clinical treatment of obesity, making it easier for obese patients to lose weight safely and minimize later weight gain.

Dr. Chen is an Assistant Professor and Research Associate in Molecular Pharmacology and Experimental Therapeutics at Mayo Clinic. She is a graduate of the Hong Kong University of Science and Technology, and has been at Mayo for five years.

Ping Chen PhD