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A Phase IIA study using intrathecal treatment of autologous adipose-derived mesenchymal stem cells for amyotrophic lateral sclerosis

Research Grant Recipient: Nathan P. Staff, MD, PhD

Grant Period: 2016-2018

Award Value: $497,086

Site: Mayo Clinic

Click here to read Staff's First Year Progress Report

Read Staff’s most recent interim report here

Project Summary:

The overall objective of this proposal is to conduct a multi-site, placebo-controlled Phase IIA clinical trial to obtain clinical data on the safety, efficacy and mechanism of action of intrathecal injection of adipose-derived mesenchymal stem cells as a regenerative therapy for the treatment of the incurable condition, amyotrophic lateral sclerosis.

Dr. Staff is an Assistant Professor of Neurology at Mayo Clinic.