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Personalized Drug Screening for Patients with Age-related Macular Degeneration using iPSC-RPE

Research Award Recipient: Deborah Ferrington, PhD

Award Value: $250,000

Research Focus: age-related macular degeneration

From the Investigator:

Age-related macular degeneration (AMD) is a chronic disease that causes central vision loss and affects one's ability to read, drive, and recognize faces. There are currently no treatments for “dry” AMD, which includes ~80% of AMD patients in Minnesota. Dry AMD is associated with death of the retinal pigment epithelial (RPE) cells that is largely due to a loss in mitochondrial function.The overall goal of this research is to develop a therapy for patients with dry AMD by identifying drugs that will enhance mitochondrial function, thereby preserving the RPE.