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Generating human neural stem and progenitor cells in a porcine model through blastocyst complementation

Research Grant Recipient: Ann M. Parr, MD, PhD

Grant Period: 2016-2018

Award Value: $250,000

Site: University of Minnesota

Click here to read Parr's First Year Progress Report

Click here to read Parr's Final Report

Project Summary:

Porcine blastocyst complementation utilizing human pluripotent stem cells (hPSCs) is a potentially transformative approach that could generate whole organs, specific tissues, or discrete cell populations to be harvested for clinical use. Here we propose to utilize interspecies complementation by injecting hPSCs into porcine blastocysts engineered to lack specific endogenous tissues.  The main goal of this project is to generate human neural stem cells and their progeny utilizing this novel approach.

Dr. Parr is an Assistant Professor in the Department of Neurosurgery and the Director of Spinal Neurosurgery at the University of Minnesota.