Circadian rhythm-based differentiation of iPS cells to cardiomyocytes
Research Grant Recipient: Nobuaki Kikyo, MD, PhD
Award Value: $250,000
Research Focus: Stem cell differentiation
Project Summary: Many regenerative therapies are based on using a patient’s own cells to create induced pluripotent stem (iPS) cells that can then be differentiated (transformed) into other cell types that the patient needs. This investigator’s previous research found that differentiation of human iPS cells to cardiomyocytes is regulated by circadian rhythms (like our internal body clock). This project hopes to establish a new way to accelerate the differentiation process, which will allow treatments to reach patients faster.
Dr. Kikyo is an Associate Professor in the Department of Genetics, Cell Biology, and Development, and a member of the Stem Cell Institute at the University of Minnesota. His research interests include chromatin remodeling in iPS cells, direct conversion of fibroblasts to cardiomyocytes, and the role of long non-coding RNA in stem cells.