Discovery Knows No Bounds

Discovery knows no bounds

© Copyright 2019 Regenerative Medicine Minnesota

Addressing the source of Parkinson's disease

Research Grant Recipient: Jonathan S. Marchant, PhD

Grant Period: 2016-2018

Award Value: $250,000

Site: University of Minnesota

Click here to read Marchant's First Year Progress Report

Click here to read Marchant's Final Report

Project Summary:

There is a key need to generate new drug treatments for neurodegenerative diseases that stop disease progression rather than just mask symptoms. In this regard, our team has recently discovered that analogs of NAADP - a potent second messenger - are able to reverse cellular defects seen in cells isolated from patients with Parkinson’s disease. To understand whether this therapy has clinical potential, we need to optimize the properties of these NAADP analogs for use in vivo and assess the beneficial effects of newly generated lead compounds in assays of neuronal regeneration and viability.

Dr. Marchant completed this research as a Professor in the Department of Pharmacology and a member of the Stem Cell Institute at the University of Minnesota. Dr. Marchant is currently the Marcus Professor and Chair of Cell Biology, Neurobiology and Anatomy at the Medical College of Wisconsin.