Activating the Hippo pathway effector YAP to augment liver regeneration

The goal of this proposal is to speed up liver regeneration by activation a regeneration pathway with a drug treatment. This will be tested in multiple models, including models in which regeneration is not as good at baseline. Positive results would provide a potential treatment to improve liver function in patients suffering from liver failure.

Year 1 Progress Report:

Mayo Clinic
Rory Smoot, MD