Innovators of the Future: Community-Based Science Module, Red Lake

Innovators of the Future: Community-Based Summer Science Program, Red Lake Nation, is the entry point to a comprehensive Native American science and research pipeline at Ctr. of American Indian & Minority Health, UMN Medical School Duluth. This community-based program provides science, math, and research exploration for Red Lake 3rd-6th grade children. The community designs activity to suit their children’s unique needs while building foundations for futures in science, research, and regenerative medicine.

Red Lake and Leech Lake
Anna Wirta Kosobuski, EdD
2016-2017

Development of A Novel Adult Stem Cell-based Drug Discovery Platform at Mayo Clinic

Using the extensive biobank of human induced pluripotent stem cells (n > 250) housed within the Mayo Clinic Center for Regenerative Medicine Biotrust, our goal is to develop a technical platform for the screening of novel drugs as well as drug libraries. By capitalizing on this extensive, stem cell-based resource, we aim to develop novel therapeutic options for Minnesota's patient population.

Mayo Clinic
Dennis Wigle, MD, PhD
2016-2017

Regenerative Medicine Bioreactor Drive System Development

This grant will fund the development of a fully-automated, computer-controlled drive system that will provide pulsatile flow to a large number of bioreactor chambers. The dynamic flow generated by this drive system can be used for cardiovascular regenerative medicine applications (primary goal) but can easily be adapted for orthopaedic or other engineered tissue applications that require oscillatory flow. This project will close the following gaps by: 

ST3 Development Corporation
Kent Vilendrer, MS, MBA
2016-2017

Bioreactor for GMP manufacturing of Tissue Engineered Vascular Graft for Pediatric Regeneration

The project aims at developing a bioreactor system for tissue engineered vascular grafts for pediatric regenerative applications. The specialized bioreactor design will meet GMP manufacturing regulatory requirement and will be utilized for manufacturing of vascular grafts for FDA submission and eventual clinical use.

University of Minnesota
Zeeshan H. Syedain, PhD
2016-2017

Airway cell and nutrient delivery device for regenerative lung tissue

The purpose of this project is to develop means for delivering cells and nutrients to the airways of regenerative lung tissue. A novel aerosolizing catheter (developed for intra-tracheal drug delivery) will be adapted to an existing whole-lung bioreactor. By the end of this one-year project, we expect to have a device capable of coating the walls of the trachea and the two bronchi with cells, nutrients and other agents, as needed for successfully growing the regenerative lung tissue.

MSP Corporation
Amir A. Naqwi, PhD
2016-2017